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OZONE IN ACTION
How does Ozone act in treatment of non-healing leg ulcers?
• Improve blood circulation and tissue oxygenation
• Stimulates immune system and kills pathogens
• Increases and activates body’s own antioxidants and radical scavengers
1. Improve blood circulation and tissue oxygenation
• Increases Oxygen release at tissue level by increasing 2, 3 DPG
• Causes vasodilatation by producing Nitric Oxide
• Ozone increases the level of ATP which influences membrane potential making RBCs more elastic and pliable.
2. Stimulates immune system and kills pathogens
A. Leucocytes, mainly Helper T Lymphocytes
Ozone leads to modification of cytokine synthesis within the immunocompetent cells with increase/decrease in pro inflammatory/anti inflammatory cytokines like IL-6, IL-4, and TNF- a, IFN- ß, IFN - ?, IL-2 and IL-10.
B. Platelets
Ozone stimulated platelets produces
PDGF (Platelet derived Growth Factor)
A chemo tactic factor, enhances fibroblast proliferation and EC matrix production.
TGF ß (Tumor Growth Factor ß)
Promotes deposition of collagen and matrix and induces angiogenesis along with other factors.
IL8 (Interleukin 8)
Causes chemo tactic gradient, aggregation of leucocytes and killing of pathogens
Ozone increases prostacyclins and decreases Thromboxane A2 levels thus favoring vasodilatation
C. Germicidal Ozone
Ozone has powerful bactericidal, fungicidal and virostatic properties that are widely used in disinfecting infected wounds.
• Ozone attacks PUFA in the bacterial cell membrane causing alternation of the membrane. This increases its porosity leading to cell damage, cell rupture and death.
• Indirectly, by activating macrophages and T cells, it leads to phagocytes and antibody production; effectively killing
the bacteria.
• Ozone induces synthesis of IFN which blocks viral replication.
• Ozone in a higher concentration attacks fungi.
3. Increases and activates body’s own antioxidants and radical scavengers
Despite being a powerful oxidant, Ozone stimulates body’s own antioxidant enzymes like glutathione, peroxides,catalase and super oxide disputes and prepare it for subsequent oxidative stress.
 DISEASES & TREATMENT
OZONE IN ACTION
OZONE THERAPIES
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